CultureOne
Alfa Laval CultureOne™ is a premium range of separators designed for single-use bioprocessing. With proven innovations for gentle product handling and enhanced yield in cell harvesting, CultureOne™ delivers unmatched separation efficiency for high-density cell cultures in biopharmaceutical processing.
Single-use centrifuges for improved cell harvesting
- Proven product recovery yields of up to 99% in single-use bioprocessing
- Easily scalable to larger Alfa Laval stainless steel separators
- 50 to 80% less water, energy, and cleaning agents compared to filter-based harvesting methods – with only a fraction of plastics
- Faster harvesting at large volumes and high cell densities
- Compact design and fast batch changeover
With Alfa Laval CultureOne™ separators, you can maximize efficiency in single-use bioprocessing, ensuring optimal results from your cell harvesting processes. These separators deliver higher product yields compared to other single-use centrifuge technologies, with proven recovery rates of up to 99%. The Hermetic Design of the CultureOne™ separator ensures gentle treatment, reducing cell lysis and avoiding foaming—making downstream purification more effective and reliable for biopharmaceutical processing.
Featuring Alfa Laval Spinsert™, our patented single-use disc stack, these separators enable quick setup and replacement, ensuring fast batch changeovers and seamless integration into single-use bioprocessing workflows.
With superior separation performance, CultureOne™ separators provide a clear centrate with minimal remaining solids content, significantly reducing the need for secondary filtration and lowering the ecological footprint.
Designed for ease of use, CultureOne™ separators can operate as stand-alone units or as part of a centralized system. Their advanced automation and connectivity ensure complete data integrity, fully compliant with 21 CFR Part 11, meeting the rigorous demands of biopharmaceutical processing.
Osvedčené a publikované
V októbri 2020 bola v časopise BioProcess International uverejnená štúdia, ktorá podrobne opisuje výkonnosť systému CultureOne Primo. Štúdia vykonaná v spolupráci so spoločnosťou Genentech preukázala mimoriadne účinnú separáciu s výťažnosťou až 99 %. V našom webinári odborníci spoločnosti Alfa Laval diskutujú o výsledkoch tejto štúdie. Ak sa chcete dozvedieť viac, pozrite si video a prečítajte si bielu knihu.
Sortiment produktov CultureOne
Separátory CultureOne zvyšujú výťažnosť produktov a umožňujú efektívnejší pracovný postup pri spracovaní na jedno použitie v biofarmaceutickom priemysle, od výskumu a vývoja až po výrobu.
CultureOne Primo
- Kapacita spracovania: 240 litrov za hodinu
- Výťažnosť produktu: až 99 %
CultureOne Maxi
- Kapacita spracovania: 720 litrov za hodinu
- Výťažnosť produktu: až 99 %
* Údaje o kapacite sa vzťahujú na prívodné inokulované bunkové kultúry cicavcov. Skutočný výkon procesu závisí od vlastností jednotlivých materiálov.
Ako to funguje
How this single-use centrifuge enhances cell harvesting in biopharma?
Curious about the CultureOne™ separators? In this short animation, you can explore how these advanced systems support cell harvesting.
Main facts about CultureOne™
Improving yields at every scale
The CultureOne separation platform is designed to maximize the potential of every cell culture, delivering unparalleled yields, ensuring product quality with utmost security, and minimizing additional lysis. The range ensures consistent performance throughout the transition from R&D to full-scale production, allowing for seamless scalability.
Developed with the industry to meet the most challenging demands
The CultureOne separation system was developed in close collaboration with leading biopharmaceutical manufacturers. Its unique performance has been verified in a wide range of processes to ensure it can meet ever-changing demands.
Less waste in single-use processing
With CultureOne separators, you can reduce the amount of water, chemicals, and plastic consumables required for single-use biopharma processing by 50 to 80%. The result is lower costs and added sustainability.
Are you considering single-use technology for biopharmaceutical manufacturing?
Why switch to single-use processing?
A single-use separation system secures patient safety by eliminating the risk of cross-contamination between batches. Single-use processing also enables a reduced footprint and increased flexibility, with no need for sterilization: empowering manufacturers to bring new treatments to market faster than ever before.
A better harvest with centrifugal separation
Many single-use harvesting systems cannot efficiently separate high-density cell cultures. The resulting product loss dramatically impacts the productivity and profitability of biopharmaceutical operations. CultureOne overcomes this problem by combining high-efficiency centrifugal separation with secure and convenient single-use processing.
Safety and quality with Spinsert™
CultureOne's performance is based on the Spinsert, a patented single-use disposable bowl and disc stack assembly – fully sterilized and ready for processing. Easy to set up and replace, it ensures fast batch changeover.
Get the answers you need
Visit the Q&A section for answers to some of the most common questions about CultureOne and its potential – or send your question to our experts.
Services
Rozšírenie výkonu vášho zariadenia
Naša špecializovaná globálna servisná sieť vás podporuje prostredníctvom náhradných dielov a odborných znalostí, kdekoľvek sa nachádzate a kedykoľvek ich potrebujete. Zabezpečením dlhšej prevádzky bez prestojov, dostupnosti a optimalizácie vám prinášame pokoj a pomáhame vám maximalizovať návratnosť investícií. Môžeme Vám pomôcť integrovať naše služby do dohody o poskytovaní služieb so spoločnosťou Alfa Laval v záujme predvídateľnej a bezstarostnej prevádzky.
Inovácie na poli separácie
Chceli by ste sa dozvedieť viac o našich inováciách v oblasti separácie? Kliknite na nasledujúci odkaz. Spoločnosť Alfa Laval vyvinula prvý tanierový bubnový separátor a na poli vývoja odstreďovacej technológie je lídrom už viac ako jedno storočie. Radi sa s vami podelíme o našu odbornosť, ktorú sme pri tom získali. V časti vedomostná základňa – poznatky z oblasti separácie – sa dozviete viac o pokroku v tejto oblasti separácie a o progrese spoločnosti Alfa Laval k ďalšej technologickej revolúcii.
Test, validate, and scale up your next separation solution
Whether upgrading your production line or running a proof of concept, Alfa Laval helps you choose the right separator solution with confidence. Simply get in touch to arrange a consultation and trial at one of our test centres, or to rent a unit for onsite testing.
